The SIES Arts, Science and Commerce College was inaugurated on 20 of June 1960 by Shri Y. B. Chavan, the first Chief Minister of Maharashtra to serve the ever-growing educational needs of students from North and Central Mumbai Suburbs, and was the gift of the South Indians in Mumbai to the then newly-born State of Maharashtra. The Commerce Stream at the Degree level was started in 1980-81. Affiliated to the University of Mumbai, the college has an impressive strength of over 4,000 students drawn from all sections of this cosmopolitan city.

Excellent results at various University and Board examinations, and coveted awards??? and merit positons bagged by the students have placed the S.I.E.S. College among the most outstanding institutions in the city. The college has attained its position due to committment and dedication of Principals like Prof. A. B. Shah (1960-63), Prof. Ram Joshi (1963-77), who later became the Vice-Chancellor, University of Mumbai, Prof. P. S. Ramaswamy (1977-87), Prof. K. M. Apte (1987-89), Prof. S. Ramanathan (1989-1996), Prof. V. Padmanaban (1996-2003), Prof. R. Gopalkrishnan (in charge Principal 2003-2005) and unstinted support from their competent and highly qualified colleagues who have given their very best to the students and to the institution.

This illustrious line is continued with the appointment of Dr. Harsha Mehta as the Principal of the college with effect from 30 April 2005. The students of the college, with their exemplary discipline, serious academic, extra and co-curricular pursuits and excellent rapport with their teachers, have greatly contributed to make this college a name to reckon with in academics and other fields.